The purpose of this program is to provide services to those at highest risk for HIV and substance use disorders, especially racial/ethnic males ages 13-24 at risk for HIV/AIDS including males who have sex with other males (MSM). The program will place a particular emphasis on those individuals who are not in stable housing in communities with high incidence and prevalence rates of substance misuse and HIV infection. It will provide opportunities to enhance outreach to the population of focus and assist them in receiving HIV medical care. The program proposes to use a navigation approach (Community Health Workers, Neighborhood Navigators, and Peer Support Specialists) to expedite services for these populations. Community-based organizations will be provided the opportunity to deliver comprehensive HIV/AIDS-related support services and transition assistance (substance misuse prevention and HIV medical care, housing, employment, family, education and prescription drug assistance services) that will reduce morbidity and mortality for this high risk group.